Making designer mutants in model organisms
نویسندگان
چکیده
منابع مشابه
Model organisms
The explosion of genomic information and the need to search for gene homologies make it more important than ever that genetic and biochemical data from model organisms should be organized in an accessible way — which is where online databases come into their own. In previous issues, The spider dealt with online resources for yeast and Caenorhabditis elegans (see Curr Biol 1998, 8:R670), Escheri...
متن کاملModel organisms
For more than a century, research scientists have been accumulating genetic and biochemical data on model organisms. Now, the explosion of genomic information and the need to search for gene homologies makes it more important than ever that these data should be organized in an accessible way — which is where online databases come into their own. The Spider kicks off with yeast and Caenorhabditi...
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MOTIVATION When working with non-model organisms, few if any species-specific markers are available for phylogenetic, phylogeographic and population studies. Therefore, researchers often try to adapt markers developed in distantly related taxa, resulting in poor amplification and ascertainment bias in their target taxa. Markers can be developed de novo and anonymous nuclear loci (ANL) are provi...
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Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany (T.L.), Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA (M.M.B.), Department of Anesthesiology, Division of Basic Research and Washington University Pain Center and Department of Anatomy and Neurobiology and Division of Biological and Biomedical Sciences, Wa...
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The correct control of gene expression is essential for the proper development of organisms. Abnormal expression of genes can lead to cancerous growth and certain diseases. To understand how gene expression is controlled on a genome-wide scale, methods for assaying transcription factor binding sites are required. There are two prevailing techniques for mapping protein-chromatin interactions, Ch...
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ژورنال
عنوان ژورنال: Development
سال: 2014
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.102186